Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50387814
Substrate
n/a
Meas. Tech.
ChEMBL_828612 (CHEMBL2060169)
IC50
10.5±n/a nM
Citation
 Bai, R; Wei, Z; Liu, J; Xie, W; Yao, H; Wu, X; Jiang, J; Wang, Q; Xu, J Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. Bioorg Med Chem 20:4661-7 (2012) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50387814
Synonyms:
CHEMBL2058375
Type:
Small organic molecule
Emp. Form.:
C29H29FN4O3S
Mol. Mass.:
532.629
SMILES:
CCCCc1nc2ccc(F)cc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Structure:
Search PDB for entries with ligand similarity: