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Target
Cathepsin D
Ligand
BDBM50390634
Substrate
n/a
Meas. Tech.
ChEMBL_835454 (CHEMBL2072160)
IC50
540±n/a nM
Citation
 Vaiana, N; Marzahn, M; Parapini, S; Liu, P; Dell'Agli, M; Pancotti, A; Sangiovanni, E; Basilico, N; Bosisio, E; Dunn, BM; Taramelli, D; Romeo, S Antiplasmodial activities of 4-aminoquinoline-statine compounds. Bioorg Med Chem Lett 22:5915-8 (2012) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50390634
Synonyms:
CHEMBL2069613
Type:
Small organic molecule
Emp. Form.:
C47H62ClN7O7
Mol. Mass.:
872.491
SMILES:
CCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccc(Oc2ccc(cc2)C(=O)N[C@@H](C)C(=O)NCCCNc2ccnc3cc(Cl)ccc23)cc1)[C@@H](C)CC |r|
Structure:
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