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Found 50 with Last Name = 'bosisio' and Initial = 'e'
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50323737(CHEMBL1213687 | N-((2S)-1-((2S)-6-amino-1-(4-(6-me...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200018((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  1nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50390636(CHEMBL2069615)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50390637(CHEMBL2069616)
Affinity DataKi:  1.90nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50390633(CHEMBL2069612)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50390635(CHEMBL2069614)
Affinity DataKi:  2.60nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50390634(CHEMBL2069613)
Affinity DataKi:  3.80nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200018((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200015((S)-2-(2S-(4-(4-(((2S,3S)-1-((3S,4S)-1-(butylamino...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200019((S)-2-(2S-(4-(4-(((2S,3S)-1-((3S,4S)-1-(butylamino...)
Affinity DataKi:  11nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200017((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(6-amino-1-...)
Affinity DataKi:  11nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200020((3S,4S)-4-((2S,3S)-2-(4-(4-((4-(6-methoxyquinolin-...)
Affinity DataKi:  11nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200015((S)-2-(2S-(4-(4-(((2S,3S)-1-((3S,4S)-1-(butylamino...)
Affinity DataKi:  11nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200021((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-(1-(4-(6-methoxyqu...)
Affinity DataKi:  12nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200019((S)-2-(2S-(4-(4-(((2S,3S)-1-((3S,4S)-1-(butylamino...)
Affinity DataKi:  17nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200014((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  26nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200017((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(6-amino-1-...)
Affinity DataKi:  33nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200023((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  58nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50146527((3S,4S)-N-butyl-3-hydroxy-6-methyl-4-((2S,3S)-3-me...)
Affinity DataKi:  59nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200014((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  74nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200020((3S,4S)-4-((2S,3S)-2-(4-(4-((4-(6-methoxyquinolin-...)
Affinity DataKi:  81nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200023((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-me...)
Affinity DataKi:  103nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50146524((S)-3-(S)-Hydroxy-4-{(S)-3-methyl-2-[2-(naphthalen...)
Affinity DataKi:  110nMAssay Description:In vitro binding affinity towards Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50223627(CHEMBL3215350)
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200016((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(6-(tert-bu...)
Affinity DataKi:  230nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50200016((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(6-(tert-bu...)
Affinity DataKi:  403nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50146527((3S,4S)-N-butyl-3-hydroxy-6-methyl-4-((2S,3S)-3-me...)
Affinity DataKi:  727nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50200021((3S,4S)-4-((2S,3S)-2-(4-(4-((S)-(1-(4-(6-methoxyqu...)
Affinity DataKi:  765nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366912(CHEMBL1790774)
Affinity DataIC50:  0.590nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366909(CHEMBL1790773)
Affinity DataIC50:  1.5nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366908(CHEMBL1790772)
Affinity DataIC50:  9.60nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272529(3,7-Bis(2-hydroxyethyl)icaritin | CHEMBL498486)
Affinity DataIC50:  74nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  75nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50146530((S)-2-[4-(4-{(S)-1-[(S)-1-((S)-2-Butylcarbamoyl-1-...)
Affinity DataIC50:  123nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366910(CHEMBL1790776)
Affinity DataIC50:  135nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272526(CHEMBL497293 | Icariside II)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human PDE6CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50390633(CHEMBL2069612)
Affinity DataIC50:  220nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50390635(CHEMBL2069614)
Affinity DataIC50:  300nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272528(7-(2-Hydroxyethyl)-3-O-rhamnosylicariin | CHEMBL50...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366911(CHEMBL1790775)
Affinity DataIC50:  396nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50390634(CHEMBL2069613)
Affinity DataIC50:  540nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50240974(2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-8-(3-met...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50146528(6-Amino-2-(S)-amino-hexanoic acid [4-(6-methoxy-qu...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272527(3-hydroxy-7-o-beta-glucose-8-prenyl-4'-methoxy Chr...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50027363(CHEBI:78420 | Icariin)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272529(3,7-Bis(2-hydroxyethyl)icaritin | CHEMBL498486)
Affinity DataIC50:  3.09E+4nMAssay Description:Inhibition of human PDE6CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50272557(3,7-dimethanesulfonyl-8-prenyl-4'-methoxy Chrysin ...)
Affinity DataIC50:  4.55E+4nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed