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Target
Fatty-acid amide hydrolase 2
Ligand
BDBM50394620
Substrate
n/a
Meas. Tech.
ChEMBL_857738 (CHEMBL2168765)
IC50
>10000±n/a nM
Citation
 Keith, JM; Apodaca, R; Tichenor, M; Xiao, W; Jones, W; Pierce, J; Seierstad, M; Palmer, J; Webb, M; Karbarz, M; Scott, B; Wilson, S; Luo, L; Wennerholm, M; Chang, L; Brown, S; Rizzolio, M; Rynberg, R; Chaplan, S; Breitenbucher, JG Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate. ACS Med Chem Lett 3:823-827 (2012) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 2
Synonyms:
AMDD | Amidase domain-containing protein | Anandamide amidohydrolase 2 | FAAH2 | FAAH2_HUMAN | Oleamide hydrolase 2
Type:
PROTEIN
Mol. Mass.:
58325.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_857738
Residue:
532
Sequence:
MAPSFTARIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDVVQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQELFLCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLRYSNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCPGKF
  
Inhibitor
Name:
BDBM50394620
Synonyms:
CHEMBL2164602
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O2
Mol. Mass.:
422.907
SMILES:
Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1
Structure:
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