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Found 941 with Last Name = 'chaplan' and Initial = 's'
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM23120(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of rat FAAH preincubated for 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50052442((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]resiniferatoxin from human Transient receptor potential vanilloid 1 receptor; (n=2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50402675(CHEMBL2207348)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254080((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50402675(CHEMBL2207348)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of rat FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254080((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50235441(4-(1-(3-isopropylbenzyl)piperidin-4-yl)-1-(oxazol-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50174997(CHEMBL3809683)
Affinity DataIC50:  1nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254325(CHEMBL469302 | N7-(4-tert-butylphenyl)-N2-(2,6-dic...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254077(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50174990(CHEMBL3809293)
Affinity DataIC50:  1nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50448310(CHEMBL3121143)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50174984(CHEMBL3809841)
Affinity DataIC50:  1.30nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50245066(CHEMBL527204 | N-(benzo[c][1,2,5]thiadiazol-4-yl)-...)
Affinity DataIC50:  1.35nMAssay Description:Inhibition of rat FAAH preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Affinity DataIC50:  1.40nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50350557(CHEMBL1812715)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254154(CHEMBL468470 | N2-(2-chloro-6-methylphenyl)-N7-(4-...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50371898(CHEMBL270189)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254326(2-(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]py...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254421(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254077(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50245066(CHEMBL527204 | N-(benzo[c][1,2,5]thiadiazol-4-yl)-...)
Affinity DataIC50:  2.02nMAssay Description:Inhibition of human FAAH preincubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50560624(CHEMBL4747373)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of rat FAAH1 incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50174988(CHEMBL3808688)
Affinity DataIC50:  2.40nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50371893(CHEMBL255146)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50560624(CHEMBL4747373)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human FAAH1 incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50402695(CHEMBL2207356)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50402695(CHEMBL2207356)
Affinity DataIC50:  2.70nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254136(CHEMBL469297 | N2-(2,6-dichlorophenyl)-N7-(4-(trif...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254078(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50402692(CHEMBL2207358)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50350557(CHEMBL1812715)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50371894(CHEMBL256009)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50448297(CHEMBL3121113)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254421(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254324(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254376(CHEMBL467851 | N2-(2,6-dichlorophenyl)-N7-(4-(meth...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254078(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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