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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50394621
Substrate
n/a
Meas. Tech.
ChEMBL_857858 (CHEMBL2169491)
IC50
120±n/a nM
Citation
 Keith, JM; Apodaca, R; Tichenor, M; Xiao, W; Jones, W; Pierce, J; Seierstad, M; Palmer, J; Webb, M; Karbarz, M; Scott, B; Wilson, S; Luo, L; Wennerholm, M; Chang, L; Brown, S; Rizzolio, M; Rynberg, R; Chaplan, S; Breitenbucher, JG Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate. ACS Med Chem Lett 3:823-827 (2012) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50394621
Synonyms:
CHEMBL2164605 | US9169224, 26
Type:
Small organic molecule
Emp. Form.:
C19H22BrN3O3
Mol. Mass.:
420.3
SMILES:
COc1cc(Br)cc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1O
Structure:
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