Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 8
Ligand
BDBM50423246
Substrate
n/a
Meas. Tech.
ChEMBL_454278 (CHEMBL903462)
IC50
25±n/a nM
Citation
 Jin, J; Wang, Y; Wang, F; Kerns, JK; Vinader, VM; Hancock, AP; Lindon, MJ; Stevenson, GI; Morrow, DM; Rao, P; Nguyen, C; Barrett, VJ; Browning, C; Hartmann, G; Andrew, DP; Sarau, HM; Foley, JJ; Jurewicz, AJ; Fornwald, JA; Harker, AJ; Moore, ML; Rivero, RA; Belmonte, KE; Connor, HE Oxazolidinones as novel human CCR8 antagonists. Bioorg Med Chem Lett 17:1722-5 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50423246
Synonyms:
CHEMBL245568 | SB-649701
Type:
Small organic molecule
Emp. Form.:
C27H28N4O3
Mol. Mass.:
456.5362
SMILES:
COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1
Structure:
Search PDB for entries with ligand similarity: