Reaction Details Report a problem with these data
Target
Probable G-protein coupled receptor 142
Ligand
BDBM50437411
Substrate
n/a
Meas. Tech.
ChEMBL_972706 (CHEMBL2410915)
EC50
28±n/a nM
Citation
 Toda, N; Hao, X; Ogawa, Y; Oda, K; Yu, M; Fu, Z; Chen, Y; Kim, Y; Lizarzaburu, M; Lively, S; Lawlis, S; Murakoshi, M; Nara, F; Watanabe, N; Reagan, JD; Tian, H; Fu, A; Motani, A; Liu, Q; Lin, YJ; Zhuang, R; Xiong, Y; Fan, P; Medina, J; Li, L; Izumi, M; Okuyama, R; Shibuya, S Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 4:790-4 (2013) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM50437411
Synonyms:
CHEMBL2409022
Type:
Small organic molecule
Emp. Form.:
C20H26N8O2
Mol. Mass.:
410.4728
SMILES:
CCOCc1c(cnn1-c1ncc(C)c(n1)N1CCC1)C(=O)NCc1cncn1C
Structure:
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