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Target
DNA (cytosine-5)-methyltransferase 3-like
Ligand
BDBM50448489
Substrate
n/a
Meas. Tech.
ChEMBL_1294383 (CHEMBL3129168)
IC50
27000±n/a nM
Citation
 Valente, S; Liu, Y; Schnekenburger, M; Zwergel, C; Cosconati, S; Gros, C; Tardugno, M; Labella, D; Florean, C; Minden, S; Hashimoto, H; Chang, Y; Zhang, X; Kirsch, G; Novellino, E; Arimondo, PB; Miele, E; Ferretti, E; Gulino, A; Diederich, M; Cheng, X; Mai, A Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem 57:701-13 (2014) [PubMed]  Article 
Target
Name:
DNA (cytosine-5)-methyltransferase 3-like
Synonyms:
DNM3L_HUMAN | DNMT3L
Type:
PROTEIN
Mol. Mass.:
43578.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108147
Residue:
386
Sequence:
MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL
  
Inhibitor
Name:
BDBM50448489
Synonyms:
CHEMBL3126651
Type:
Small organic molecule
Emp. Form.:
C31H23N5O
Mol. Mass.:
481.5472
SMILES:
O=C(Nc1ccc(Nc2ccnc3ccccc23)cc1)c1ccc(Nc2ccnc3ccccc23)cc1
Structure:
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