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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50011135
Substrate
n/a
Meas. Tech.
ChEMBL_1351579 (CHEMBL3268547)
EC50
5.0±n/a nM
Citation
 Pinard, E; Alberati, D; Alvarez-Sanchez, R; Brom, V; Burner, S; Fischer, H; Hauser, N; Kolczewski, S; Lengyel, J; Mory, R; Saladin, C; Schulz-Gasch, T; Stalder, H 3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors. ACS Med Chem Lett 5:428-33 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | Glyt1 | SC6A9_MOUSE | Slc6a9 | Solute carrier family 6 member 9
Type:
PROTEIN
Mol. Mass.:
76552.86
Organism:
Mus musculus
Description:
ChEMBL_1351579
Residue:
692
Sequence:
MIGGDTRAASAHPGMASAQGPVATPSPEQPFPGTTSVSLARPVLRVWHGAHSSGLLPNLIAQHSPAMAQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRFQDSRI
  
Inhibitor
Name:
BDBM50011135
Synonyms:
CHEMBL3259928
Type:
Small organic molecule
Emp. Form.:
C22H25F3N2O2S
Mol. Mass.:
438.506
SMILES:
COc1cc(cc(SC)c1C(=O)N[C@]1(CCCN(C)C1)c1ccccc1)C(F)(F)F |r|
Structure:
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