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Target
Ras guanyl-releasing protein 3
Ligand
BDBM50017890
Substrate
n/a
Meas. Tech.
ChEMBL_1364407 (CHEMBL3294519)
Ki
0.340000±n/a nM
Citation
 Garcia, LC; Donadío, LG; Mann, E; Kolusheva, S; Kedei, N; Lewin, NE; Hill, CS; Kelsey, JS; Yang, J; Esch, TE; Santos, M; Peach, ML; Kelley, JA; Blumberg, PM; Jelinek, R; Marquez, VE; Comin, MJ Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorg Med Chem 22:3123-40 (2014) [PubMed]  Article 
Target
Name:
Ras guanyl-releasing protein 3
Synonyms:
GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3
Type:
PROTEIN
Mol. Mass.:
78335.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1364407
Residue:
690
Sequence:
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG
  
Inhibitor
Name:
BDBM50017890
Synonyms:
CHEMBL3289012
Type:
Small organic molecule
Emp. Form.:
C24H31NO5
Mol. Mass.:
413.5066
SMILES:
CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccc3n(C)ccc3c2)C(=O)O1
Structure:
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