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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50115217
Substrate
n/a
Meas. Tech.
ChEMBL_1513746 (CHEMBL3610856)
IC50
1100±n/a nM
Citation
 Schuler, AD; Engles, CA; Maeda, DY; Quinn, MT; Kirpotina, LN; Wicomb, WN; Mason, SN; Auten, RL; Zebala, JA Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability. Bioorg Med Chem Lett 25:3793-7 (2015) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50115217
Synonyms:
CHEMBL3609005 | USRE47740, Compound 18 | USRE48547, Compound 18
Type:
Small organic molecule
Emp. Form.:
C20H19BFN3O3
Mol. Mass.:
379.193
SMILES:
CN(Cc1ccc(cc1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: