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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM50128687
Substrate
n/a
Meas. Tech.
ChEMBL_1522561 (CHEMBL3631914)
IC50
500±n/a nM
Citation
 Charnley, AK; Convery, MA; Lakdawala Shah, A; Jones, E; Hardwicke, P; Bridges, A; Ouellette, M; Totoritis, R; Schwartz, B; King, BW; Wisnoski, DD; Kang, J; Eidam, PM; Votta, BJ; Gough, PJ; Marquis, RW; Bertin, J; Casillas, L Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity. Bioorg Med Chem 23:7000-6 (2015) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM50128687
Synonyms:
CHEMBL3628628
Type:
Small organic molecule
Emp. Form.:
C23H24ClN5O3
Mol. Mass.:
453.921
SMILES:
COCCNC(=O)c1ccc2n(CCOC)c(nc2c1)-c1cnc([nH]1)-c1ccc(Cl)cc1
Structure:
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