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Target
Proteinase-activated receptor 2
Ligand
BDBM50134198
Substrate
n/a
Meas. Tech.
ChEMBL_1539848 (CHEMBL3737116)
IC50
690±n/a nM
Citation
 Cho, NC; Cha, JH; Kim, H; Kwak, J; Kim, D; Seo, SH; Shin, JS; Kim, T; Park, KD; Lee, J; No, KT; Kim, YK; Lee, KT; Pae, AN Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists. Bioorg Med Chem 23:7717-27 (2015) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50134198
Synonyms:
CHEMBL1684609
Type:
Small organic molecule
Emp. Form.:
C18H21FN4O
Mol. Mass.:
328.3839
SMILES:
CCCCCNc1nc(NCc2ccco2)c2cc(F)ccc2n1
Structure:
Search PDB for entries with ligand similarity: