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Target
Serine/threonine-protein kinase Nek6
Ligand
BDBM50144963
Substrate
n/a
Meas. Tech.
ChEMBL_1556161 (CHEMBL3768615)
Kd
130±n/a nM
Citation
 Min, J; Guo, K; Suryadevara, PK; Zhu, F; Holbrook, G; Chen, Y; Feau, C; Young, BM; Lemoff, A; Connelly, MC; Kastan, MB; Guy, RK Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. J Med Chem 59:559-77 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek6
Synonyms:
NEK kinase | NEK6 | NEK6_HUMAN
Type:
PROTEIN
Mol. Mass.:
35724.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446777
Residue:
313
Sequence:
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
  
Inhibitor
Name:
BDBM50144963
Synonyms:
CHEMBL3763358
Type:
Small organic molecule
Emp. Form.:
C19H19N7O3
Mol. Mass.:
393.3993
SMILES:
COCCOc1cc2c(ncnc2cc1OC)-n1nc(nc1N)-c1ccccn1
Structure:
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