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Target
Free fatty acid receptor 1
Ligand
BDBM50157569
Substrate
n/a
Meas. Tech.
ChEMBL_1568678 (CHEMBL3791346)
EC50
1820±n/a nM
Citation
 Hansen, SV; Christiansen, E; Urban, C; Hudson, BD; Stocker, CJ; Due-Hansen, ME; Wargent, ET; Shimpukade, B; Almeida, R; Ejsing, CS; Cawthorne, MA; Kassack, MU; Milligan, G; Ulven, T Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy. J Med Chem 59:2841-6 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50157569
Synonyms:
CHEMBL3787151
Type:
Small organic molecule
Emp. Form.:
C19H18O2
Mol. Mass.:
278.345
SMILES:
OC(=O)CCc1ccc(cc1)C#CCCc1ccccc1
Structure:
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