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Target
Sphingosine-1-phosphate lyase 1
Ligand
BDBM50187501
Substrate
n/a
Meas. Tech.
ChEMBL_1590325 (CHEMBL3830364)
Ki
5000±n/a nM
Citation
 Sanllehí, P; Abad, JL; Casas, J; Bujons, J; Delgado, A Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors. Bioorg Med Chem 24:4381-4389 (2016) [PubMed]  Article 
Target
Name:
Sphingosine-1-phosphate lyase 1
Synonyms:
4.1.2.27 | S1PL | SGPL1_RAT | SP-lyase 1 | SPL 1 | Sgpl1 | Sphingosine-1-phosphate aldolase | Sphingosine-1-phosphate lyase 1 | Spl
Type:
PROTEIN
Mol. Mass.:
63781.25
Organism:
Rattus norvegicus
Description:
ChEMBL_116828
Residue:
568
Sequence:
MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQGGIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR
  
Inhibitor
Name:
BDBM50187501
Synonyms:
CHEMBL3827445
Type:
Small organic molecule
Emp. Form.:
C18H40NO4P
Mol. Mass.:
365.4883
SMILES:
CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CP(O)(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: