Reaction Details Report a problem with these data
Target
Prostaglandin G/H synthase 1 [582-599]
Ligand
BDBM11639
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
>1.00e+5±n/a nM
Citation
 Bekhit, AA; Ashour, HM; Bekhit, Ael-D; Abdel-Rahman, HM; Bekhit, SA Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents. J Enzyme Inhib Med Chem 24:296-309 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1 [582-599]
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH synthase 1 | PGH1_HUMAN | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Type:
Protein
Mol. Mass.:
1879.89
Organism:
Homo sapiens (Human)
Description:
Q6LCE7
Residue:
18
Sequence:
PDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM11639
Synonyms:
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662
Type:
Small organic molecule
Emp. Form.:
C17H14F3N3O2S
Mol. Mass.:
381.372
SMILES:
Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Structure:
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