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Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM92359
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
IC50
>2.50e+5±n/a nM
Citation
 Bannwarth, L; Goldberg, AB; Chen, C; Turk, BE Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Chem Biol 19:875-82 (2012) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM92359
Synonyms:
Gangleoidin, 4
Type:
Small organic molecule
Emp. Form.:
C17H12Cl2O7
Mol. Mass.:
399.179
SMILES:
COc1cc2OC(=O)c3c(C)c(Cl)c(O)c(Cl)c3Oc2c(C)c1C(O)=O
Structure:
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