Reaction Details Report a problem with these data
Target
Bifunctional protein GlmU
Ligand
BDBM50365075
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.35±0
IC50
3.3e+3±n/a nM
Kd
1.9e+3±n/a nM
Citation
 Buurman, ET; Andrews, B; Gao, N; Hu, J; Keating, TA; Lahiri, S; Otterbein, LR; Patten, AD; Stokes, SS; Shapiro, AB In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae. J Biol Chem 286:40734-42 (2011) [PubMed]  Article 
Target
Name:
Bifunctional protein GlmU
Synonyms:
Bifunctional protein (GlmU) | GLMU_STAAC | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | gcaD | glmU
Type:
Enzyme
Mol. Mass.:
48525.06
Organism:
Staphylococcus aureus
Description:
Q5HIH6
Residue:
450
Sequence:
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQRRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
  
Inhibitor
Name:
BDBM50365075
Synonyms:
CHEMBL1951164 | Sulfonamide, 2
Type:
Small organic molecule
Emp. Form.:
C17H20N2O5S
Mol. Mass.:
364.416
SMILES:
COc1cc(OC)c(cc1NC(C)=O)S(=O)(=O)N(C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: