Reaction Details Report a problem with these data
Target
Bifunctional protein GlmU
Ligand
BDBM92474
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.35±0
IC50
23±n/a nM
Citation
 Buurman, ET; Andrews, B; Gao, N; Hu, J; Keating, TA; Lahiri, S; Otterbein, LR; Patten, AD; Stokes, SS; Shapiro, AB In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae. J Biol Chem 286:40734-42 (2011) [PubMed]  Article 
Target
Name:
Bifunctional protein GlmU
Synonyms:
Bifunctional protein (GlmU) | GLMU_HAEIN | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU
Type:
Enzyme
Mol. Mass.:
49287.19
Organism:
Haemophilus influenzae
Description:
P43889
Residue:
456
Sequence:
MTKKALSAVILAAGKGTRMYSDLPKVLHTIAGKPMVKHVIDTAHQLGSENIHLIYGHGGDLMRTHLANEQVNWVLQTEQLGTAHAVQQAAPFFKDNENIVVLYGDAPLITKETLEKLIEAKPENGIALLTVNLDNPTGYGRIIRENGNVVAIVEQKDANAEQLNIKEVNTGVMVSDGASFKKWLARVGNNNAQGEYYLTDLIALANQDNCQVVAVQATDVMEVEGANNRLQLAALERYFQNKQASKLLLEGVMIYDPARFDLRGTLEHGKDVEIDVNVIIEGNVKLGDRVKIGTGCVLKNVVIGNDVEIKPYSVLEDSIVGEKAAIGPFSRLRPGAELAAETHVGNFVEIKKSTVGKGSKVNHLTYVGDSEIGSNCNIGAGVITCNYDGANKFKTIIGDDVFVGSDTQLVAPVKVANGATIGAGTTITRDVGENELVITRVAQRHIQGWQRPIKKK
  
Inhibitor
Name:
BDBM92474
Synonyms:
Sulfonamide, 5
Type:
Small organic molecule
Emp. Form.:
C24H22N2O8S
Mol. Mass.:
498.505
SMILES:
COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N1c2ccccc2Oc2ccccc12
Structure:
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