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Target
Vascular endothelial growth factor A
Ligand
BDBM282708
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
pH
7.5±n/a
IC50
29.0±n/a nM
Comments
extracted
Citation
 Dixon, DD; Grina, J; Josey, JA; Rizzi, JP; Schlachter, ST; Wallace, EM; Wang, B; Wehn, P; Xu, R; Yang, H Cyclic sulfone and sulfoximine analogs and uses thereof US Patent  US9884843 Publication Date 2/6/2018 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM282708
Synonyms:
4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- difluoro-3-hydroxy-1-imino-2,3-dihydro-1H-1lambda4- benzo[b]thiophene 1-oxide | US9884843, Compound 52 | US9884843, Compound 53
Type:
Small organic molecule
Emp. Form.:
C15H9F6NO3S
Mol. Mass.:
397.292
SMILES:
OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=N)(=O)C1(F)F
Structure:
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