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Target
Vascular endothelial growth factor A
Ligand
BDBM282740
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
pH
7.5±n/a
IC50
17.0±n/a nM
Comments
extracted
Citation
 Dixon, DD; Grina, J; Josey, JA; Rizzi, JP; Schlachter, ST; Wallace, EM; Wang, B; Wehn, P; Xu, R; Yang, H Cyclic sulfone and sulfoximine analogs and uses thereof US Patent  US9884843 Publication Date 2/6/2018 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM282740
Synonyms:
(R)-3-((4-bromo-2,2-difluoro-3-hydroxy-1,1-dioxido- 2,3-dihydrobenzo[b]thiophen-5-yl)oxy)benzonitrile | US9884843, Compound 84
Type:
Small organic molecule
Emp. Form.:
C15H8BrF2NO4S
Mol. Mass.:
416.194
SMILES:
O[C@@H]1c2c(ccc(Oc3cccc(c3)C#N)c2Br)S(=O)(=O)C1(F)F |r|
Structure:
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