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Target
Casein kinase I isoform epsilon
Ligand
BDBM191572
Substrate
n/a
Meas. Tech.
KinaseGlo Plus Luminescent Assay
pH
7.5±n/a
IC50
4.7e+3± 8e+2 nM
Comments
extracted
Citation
 Ursu, A; Illich, DJ; Takemoto, Y; Porfetye, AT; Zhang, M; Brockmeyer, A; Janning, P; Watanabe, N; Osada, H; Vetter, IR; Ziegler, S; Schler, HR; Waldmann, H Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol 23:494-507 (2016) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM191572
Synonyms:
6-(3-chlorophenyl)pteridine-2,4,7-triamine (15) | Epiblastin A
Type:
Small organic molecule
Emp. Form.:
C12H10ClN7
Mol. Mass.:
287.708
SMILES:
Nc1nc(N)c2nc(c(N)nc2n1)-c1cccc(Cl)c1
Structure:
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