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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM191572
Substrate
n/a
Meas. Tech.
Radiometric-Based Assay (Epiblastin A)
IC50
3.81e+4± 1.13e+4 nM
Citation
 Ursu, A; Illich, DJ; Takemoto, Y; Porfetye, AT; Zhang, M; Brockmeyer, A; Janning, P; Watanabe, N; Osada, H; Vetter, IR; Ziegler, S; Schöler, HR; Waldmann, H Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol 23:494-507 (2016) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM191572
Synonyms:
6-(3-chlorophenyl)pteridine-2,4,7-triamine (15) | Epiblastin A
Type:
Small organic molecule
Emp. Form.:
C12H10ClN7
Mol. Mass.:
287.708
SMILES:
Nc1nc(N)c2nc(c(N)nc2n1)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: