Reaction Details
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Complement factor B [470-764]
Ligand
BDBM203865
Substrate
n/a
Meas. Tech.
Human FB Proteolysis Assay (ELISA C3a)
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol 12:1105-1110 (2016) [PubMed] Article More Info.:
Target
Name:
Complement factor B [470-764]
Synonyms:
BF | BFD | CFAB_HUMAN | CFB | Complement factor B (FB) catalytic domain
Type:
Protein
Mol. Mass.:
33371.42
Organism:
Homo sapiens (Human)
Description:
P00751 (470-764 aa)
Residue:
295
Sequence:
DESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
Inhibitor
Name:
BDBM203865
Synonyms:
Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carbamoyl)pyrrolidine-1-carboxamido)-methyl)benzoate (2)
Type:
Small organic molecule
Emp. Form.:
C22H22F3N3O5
Mol. Mass.:
465.4224
SMILES:
COC(=O)c1ccccc1CNC(=O)N1CCC[C@H]1C(=O)Nc1cccc(OC(F)(F)F)c1
Structure:
