Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma [182-505]/Regulatory protein GAL4 [1-147]
Ligand
BDBM222700
Substrate
n/a
Meas. Tech.
Activation Assay
EC50
2740±n/a nM
Citation
 Miura, T; Sato, S; Yamada, H; Tagashira, J; Watanabe, T; Sekimoto, R; Ishida, R; Aoki, H; Ohgiya, T Phenylpyridine derivative and drug containing same US Patent  US9315493 Publication Date 4/19/2016 
Target
Name:
Peroxisome proliferator-activated receptor gamma [182-505]/Regulatory protein GAL4 [1-147]
Synonyms:
PPARgamma2 - DNA binding domain of Gal4
Type:
DNA-Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Regulatory protein GAL4 [1-147]
Synonyms:
DNA-binding transcription factor (GAl4) | GAL4 | GAL4_YEAST
Type:
DNA Binding
Mol. Mass.:
16874.50
Organism:
Saccharomyces bayanus (Yeast)
Description:
amino acids 1 to 147
Residue:
147
Sequence:
MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVS
  
Component 2
Name:
Peroxisome proliferator-activated receptor gamma [182-505]
Synonyms:
NR1C3 | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Type:
Protein
Mol. Mass.:
37077.80
Organism:
Homo sapiens (Human)
Description:
amino acids 182 to 505
Residue:
324
Sequence:
IHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM222700
Synonyms:
US9315493, 32
Type:
Small organic molecule
Emp. Form.:
C28H24ClF3N8O
Mol. Mass.:
580.991
SMILES:
CCCCc1nc(C)n(-c2ncc(cc2Cl)C(F)(F)F)c(=O)c1Cc1ccc(cn1)-c1ccccc1-c1nnn[nH]1 |(-7.34,.87,;-6,.1,;-4.67,.87,;-3.33,.1,;-2,.87,;-2,2.41,;-.67,3.18,;-.67,4.72,;.67,2.41,;2,3.18,;3.33,2.41,;4.67,3.18,;4.72,4.75,;3.33,5.49,;2,4.72,;.67,5.49,;6.05,5.52,;7.38,6.29,;6.82,4.19,;5.28,6.85,;.67,.87,;2,.1,;-.67,.1,;-.67,-1.44,;.67,-2.21,;2,-1.44,;3.33,-2.21,;3.33,-3.75,;2,-4.52,;.67,-3.75,;4.67,-4.52,;4.67,-6.06,;6,-6.83,;7.34,-6.06,;7.34,-4.52,;6,-3.75,;6,-2.21,;4.76,-1.3,;5.23,.16,;6.77,.16,;7.25,-1.3,)|
Structure:
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