Reaction Details Report a problem with these data
Target
Sialidase
Ligand
BDBM412952
Substrate
n/a
Meas. Tech.
Activity Inhibition Assay
Ki
6600000±0.3 nM
Citation
 Park, KH; Eom, SH; Ryu, YB; Cho, JK Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient US Patent  US10406136 Publication Date 9/10/2019 
Target
Name:
Sialidase
Synonyms:
nanI
Type:
Enzyme
Mol. Mass.:
77396.34
Organism:
Clostridium perfringens
Description:
A0A0H2YQR1
Residue:
694
Sequence:
MNYKGITLILTAAMVISGGNYVLVKGSTLDSGKNNSGYEIKVNNSENLSSLGEYKDINLESSNASNITYDLEKYKNLDEGTIVVRFNSKDSKIQSLLGISNSKTKNGYFNFYVTNSRVGFELRNQKNEGNTQNGTENLVHMYKDVALNDGDNTVALKIEKNKGYKLFLNGKMIKEVKDTNTKFLNNIENLDSAFIGKTNRYGQSNEYNFKGNIGFMNIYNEPLGDDYLLSKTGETKAKEEVLVEGAVKTEPVDLFHPGFLNSSNYRIPALFKTKEGTLIASIDARRQGGADAPNNDIDTAVRRSEDGGKTWDEGQIIMDYPDKSSVIDTTLIQDDETGRIFLLVTHFPSKYGFWNAGLGSGFKNIDGKEYLCLYDSSGKEFTVRENVVYDKDGNKTEYTTNALGDLFRNGTKIDNINSSTAPLKAKGTSYINLVYSDDDGKTWSEPQNINFQVKKDWMKFLGIAPGRGIQIKNGEHKGRIVVPVYYTNEKGKQSSAVIYSDDSGKNWTIGESPNDNRKLENGKIINSKTLSDDAPQLTECQVVEMPNGQLKLFMRNLSGYLNIATSFDGGATWDETVEKDTNVLEPYCQLSVINYSQKIDGKDAVIFSNPNARSRSNGTVRIGLINQVGTYENGEPKYEFDWKYNKLVKPGYYAYSCLTELSNGNIGLLYEGTPSEEMSYIEMNLKYLESGANK
  
Inhibitor
Name:
BDBM412952
Synonyms:
US10406136, Compound 5
Type:
Small organic molecule
Emp. Form.:
C27H32O6
Mol. Mass.:
452.5394
SMILES:
[#6]-[#8]-c1ccc(cc1-[#8]-[#6])-[#6]-1-[#6]-[#6](=O)-c2c(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])cc2-[#8]-1
Structure:
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