Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 6CHH
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50: 4.36E+3nMAssay Description:Inhibition of wild-type human full length NNMT expressed in Escherichia coli BL21(DE3) cells assessed as reduction in 1-methyl-nicotinamide formation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) using nicotinamide/SAM as substrate/co-factor measured for 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)