Compile Data Set for Download or QSAR
Report error Found 335 of affinity data for UniProtKB/TrEMBL: O60427
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245999BDBM50245999(CHEMBL4084502)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576738BDBM50576738(CHEMBL4856454 | US12473289, Example 39-27)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576738BDBM50576738(CHEMBL4856454 | US12473289, Example 39-27)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787603BDBM787603(US12473289, Example 41-1)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576739BDBM50576739(CHEMBL4879015)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245998BDBM50245998(CHEMBL4064555)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615159BDBM50615159(CHEMBL5278664)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Delta 5 desaturase (unknown origin) expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576734BDBM50576734(CHEMBL4874614)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787493BDBM787493(Ethyl(4-oxo-3-(1-(2,2,3,3,3-pentafluoropropyl)-1H-...)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576736BDBM50576736(CHEMBL4872983 | US12473289, Example 39-19)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576736BDBM50576736(CHEMBL4872983 | US12473289, Example 39-19)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535222BDBM50535222(CHEMBL4439992)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of D5D in human HepG2 cells using [14C]DGLA as substrate preincubated for 30 mins followed by substrate addition measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576737BDBM50576737(CHEMBL4855704 | US12473289, Example 39-23)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576737BDBM50576737(CHEMBL4855704 | US12473289, Example 39-23)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576735BDBM50576735(CHEMBL4868627 | US12473289, Example 39-17)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50576735BDBM50576735(CHEMBL4868627 | US12473289, Example 39-17)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787469BDBM787469(3-(4-(((1R)-2,2-Difluorocyclopropyl)methoxy)phenyl...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787377BDBM787377(8-methyl-3-(4-(2,2,2- trifluoroethoxy)phenyl)-2- (...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787366BDBM787366(3-(4- (cyclopropylmethoxy)phenyl)- 8-(methyloxy-d3...)
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787319BDBM787319(8-methoxy-3-(4-(2,2,2- trifluoroethoxy)phenyl)-2- ...)
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787351BDBM787351(8-methoxy-3-(4- propylphenyl)-2- (trifluoromethyl)...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246049BDBM50246049(CHEMBL4102458)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787559BDBM787559(3-[1-(2,2,3,3,3- pentafluoropropyl)- 1H-pyrazol-4-...)
Affinity DataIC50: 3.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787531BDBM787531(7-Chloro-3-[1-(2,2,3,3,3-pentafluoropropyl)-1H-pyr...)
Affinity DataIC50: 3.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787430BDBM787430(8-(methyl-d3)-3-(4- (2,2,2- trifluoroethoxy)phenyl...)
Affinity DataIC50: 3.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787406BDBM787406(8-Methoxy-3-(4-(2,2,3,3,3-pentafluoropropoxy)pheny...)
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787358BDBM787358(8-(methyloxy-d3)- 3-(4-(2,2,2- trifluoroethoxy) ph...)
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787423BDBM787423(8-chloro-3-(4-(2,2,2- trifluoroethoxy)phenyl)- 2-(...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246023BDBM50246023(CHEMBL4060775)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787609BDBM787609(7-fluoro-8- methoxy-3-[4- (2,2,2- trifluoroethoxy)...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787594BDBM787594(3-{1-[(3,3- difluorocyclobutyl) methyl]-1H- pyrazo...)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787611BDBM787611(3-{1-[(2,2- difluorocyclopropyl) methyl]-1H- pyraz...)
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116774BDBM50116774(CHEMBL3608796)
Affinity DataIC50: 5nMAssay Description:Inhibition of liver delta-5 desaturase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787361BDBM787361(3-(4-(cyclopropyl- methoxy)phenyl)-8- methoxy-2- (...)
Affinity DataIC50: 5.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787331BDBM787331(3-(3-fluoro-4-(2,2,2- trifluoroethoxy)phenyl)-8- m...)
Affinity DataIC50: 5.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787466BDBM787466(4-oxo-3-(4-(2,2,2- trifluoroethoxy) phenyl)-2- (tr...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787330BDBM787330(8-methoxy-3-(1-phenyl-1H- pyrazol-4-yl)-2- (triflu...)
Affinity DataIC50: 5.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787332BDBM787332(8-methoxy-3-(4- (trifluoromethoxy)phenyl)-2- (trif...)
Affinity DataIC50: 5.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787392BDBM787392(3-(4-(2,2- difluoroethoxy)phenyl)-8- (methyloxy-d3...)
Affinity DataIC50: 5.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787433BDBM787433(8-(hydroxymethyl)-3-(4- (2,2,2- trifluoroethoxy)ph...)
Affinity DataIC50: 5.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787468BDBM787468(3-(4-(((1R)-2,2-Difluorocyclopropyl)methoxy)phenyl...)
Affinity DataIC50: 5.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787398BDBM787398((4-(8-Methoxy-4-oxo-2-(trifluoromethyl)-4H-pyrido[...)
Affinity DataIC50: 5.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787396BDBM787396(3-(2-fluoro-4- (trifluoromethoxy)phenyl)- 8-methox...)
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116776BDBM50116776(CHEMBL3608798)
Affinity DataIC50: 6nMAssay Description:Inhibition of liver delta-5 desaturase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787538BDBM787538(8-methoxy-3-[1- (2,2,3,3,3- pentafluoropropyl)- 1H...)
Affinity DataIC50: 6.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787467BDBM787467(8-acetyl-3-(4-(2,2,2- trifluoroethoxy)phenyl)-2- (...)
Affinity DataIC50: 6.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787353BDBM787353(2-ethyl-8-methoxy-3-(4- (2,2,2- trifluoroethoxy)ph...)
Affinity DataIC50: 6.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787438BDBM787438(3-(4-((2,2-difluorocyclo- propyl)methoxy)phenyl)- ...)
Affinity DataIC50: 6.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787390BDBM787390(3-(4- (difluoromethoxy)phenyl)-8- methoxy-2-(trifl...)
Affinity DataIC50: 6.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetAcyl-CoA (8-3)-desaturase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 787451BDBM787451(8-amino-3-(4- (2,2,2- trifluoroeth- oxy)phenyl)-2-...)
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

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