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Report error Found 414 of affinity data for UniProtKB/TrEMBL: P19634
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50058715BDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of human NHE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485565BDBM50485565(CHEMBL465179)
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of human NHE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50234609BDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human NHE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81818BDBM81818(CHEMBL1909810 | NSC_1794 | CAS_1794 | HMA)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human NHE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201454BDBM50201454(N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-(pyr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471224BDBM50471224(CHEMBL64889)
Affinity DataIC50: 2nMAssay Description:Inhibition of NHE1 in human Platelet assessed as reduction in 22Na+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104843BDBM50104843(N-[3-(3-Bromo-4-fluoro-phenyl)-2,2-dimethyl-cyclop...)
Affinity DataIC50: 3nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270005BDBM50270005(cid_1795 | CHEMBL1909809 | CHEMBL517986 | 5'-(N-et...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human NHE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50191852BDBM50191852(2-(5-(4-fluoro-3-methylphenyl)-4-(4-(4-methyl-1H-i...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104848BDBM50104848(N-[3-(3-Ethyl-4-fluoro-phenyl)-2,2-dimethyl-cyclop...)
Affinity DataIC50: 5nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104846BDBM50104846(N-[3-(2,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 5nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396463BDBM50396463(CHEMBL2170611)
Affinity DataIC50: 5nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50191839BDBM50191839(5-(1-(5-(3-chloro-4-fluorophenyl)pyrimidin-4-yl)pi...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104856BDBM50104856(N-[3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 6nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637460BDBM50637460(CHEMBL5532364)
Affinity DataIC50: 6nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396469BDBM50396469(CHEMBL2170610)
Affinity DataIC50: 6nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104856BDBM50104856(N-[3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 6nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50191831BDBM50191831(5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-meth...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50191846BDBM50191846(5-(4-fluoro-3-methylphenyl)-2-isopropoxy-4-(4-(4-m...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50137552BDBM50137552(5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50: 8nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201465BDBM50201465(3-amino-N-(diaminomethylene)-5-(2,5-dichlorophenyl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50137552BDBM50137552(5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50: 8nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104844BDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104844BDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201443BDBM50201443(N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-(dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104844BDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637452BDBM50637452(CHEMBL5562362)
Affinity DataIC50: 10nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201470BDBM50201470(5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396471BDBM50396471(CHEMBL2170608)
Affinity DataIC50: 10nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396470BDBM50396470(CHEMBL2170609)
Affinity DataIC50: 11nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201447BDBM50201447(5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104852BDBM50104852(N-[3-(3-Methoxy-phenyl)-2,2-dimethyl-cyclopropanec...)
Affinity DataIC50: 12nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104842BDBM50104842(N-[3-(3-Chloro-phenyl)-2,2-dimethyl-cyclopropaneca...)
Affinity DataIC50: 14nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396435BDBM50396435(CHEMBL2170617)
Affinity DataIC50: 14nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396436BDBM50396436(CHEMBL2170615)
Affinity DataIC50: 14nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396443BDBM50396443(CHEMBL2170632)
Affinity DataIC50: 15nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201472BDBM50201472(3-amino-5-(5-chloro-2-methoxyphenyl)-N-(diaminomet...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396465BDBM50396465(CHEMBL2169894)
Affinity DataIC50: 15nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396464BDBM50396464(CHEMBL2170603)
Affinity DataIC50: 15nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50191849BDBM50191849(5-(3-chloro-4-fluorophenyl)-2-methoxy-4-(4-(4-meth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292303BDBM50292303(N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-meth...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396472BDBM50396472(CHEMBL2170607)
Affinity DataIC50: 16nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104862BDBM50104862(N-[3-(4-Fluoro-3-isopropyl-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50: 17nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637457BDBM50637457(CHEMBL5550005)
Affinity DataIC50: 17nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396434BDBM50396434(CHEMBL2170618)
Affinity DataIC50: 18nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396439BDBM50396439(CHEMBL2170637)
Affinity DataIC50: 18nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396440BDBM50396440(CHEMBL2170636)
Affinity DataIC50: 18nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396441BDBM50396441(CHEMBL2170635)
Affinity DataIC50: 18nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396468BDBM50396468(CHEMBL2170612)
Affinity DataIC50: 19nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396437BDBM50396437(CHEMBL2170639)
Affinity DataIC50: 19nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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