Compile Data Set for Download or QSAR
Report error Found 219 for UniProtKB: P22102
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50016662BDBM50016662(CHEMBL23278 | 2-{4-[3-(2-Amino-4-oxo-3,4,7,8-tetra...)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50016659BDBM50016659(CHEMBL23699 | 2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-h...)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50016660BDBM50016660(CHEMBL23388 | 2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-h...)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50016658BDBM50016658(CHEMBL279302 | 2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-...)
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of the GAR transformylase in MOLT-4 human leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50277355BDBM50277355(CHEMBL4177183)
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50277352BDBM50277352(CHEMBL4162649)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543845BDBM50543845(CHEMBL4643623)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534427BDBM50534427(CHEMBL4437824)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393640BDBM50393640(CHEMBL2158681)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503238BDBM50503238(CHEMBL4465095)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543843BDBM50543843(CHEMBL4636872)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503236BDBM50503236(CHEMBL4538151)
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126172BDBM50126172(CHEMBL3628344)
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171513BDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503240BDBM50503240(CHEMBL4445651)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50457435BDBM50457435(CHEMBL4214638)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171513BDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393640BDBM50393640(CHEMBL2158681)
Affinity DataIC50: 1.79nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50457435BDBM50457435(CHEMBL4214638)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354833BDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171513BDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171511BDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503239BDBM50503239(CHEMBL4557278)
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059331BDBM50059331((R)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-...)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354833BDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human KB cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs by ion-exchang...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393639BDBM50393639(CHEMBL2158682)
Affinity DataIC50: 2.03nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534430BDBM50534430(CHEMBL4471269)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126172BDBM50126172(CHEMBL3628344)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543844BDBM50543844(CHEMBL4645676)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126174BDBM50126174(CHEMBL3628346)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534427BDBM50534427(CHEMBL4437824)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50442985BDBM50442985(CHEMBL3086865)
Affinity DataIC50: 2.90nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059333BDBM50059333((R)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-...)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306576BDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as incorporation of [U-14C]-glycine into [14C]-formyl glycinamide ribon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059332BDBM50059332(2-{3-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrim...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306576BDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 3.46nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354833BDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50457432BDBM50457432(CHEMBL4205344)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534426BDBM50534426(CHEMBL4553188)
Affinity DataIC50: 5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534428BDBM50534428(CHEMBL4467936)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543847BDBM50543847(CHEMBL4638232)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50442984BDBM50442984(CHEMBL3086866 | AGF147)
Affinity DataIC50: 5.5nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534429BDBM50534429(CHEMBL4444011)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171511BDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005518BDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 5.77nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  6nMAssay Description:Inhibition of GARFTase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534431BDBM50534431(CHEMBL4447805)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171511BDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 192709BDBM192709(AGF117)
Affinity DataIC50: 7nMpH: 7.5Assay Description:GARFTase activity was determined by measuring the rate of 5,8-dideazatetrahydrofolate production in the presence of varying concentrations of antifol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50272272BDBM50272272(N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
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