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Report error Found 321 of affinity data for UniProtKB/TrEMBL: P39086
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141505(US8921370, 126 | US9656975, 126)
Affinity DataIC50: 0.320nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM85740(Dysiherbaine)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]kianic acid from recombinant GluK1 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50646139(DOMOIC ACID)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H](2S, 4R)-4-MeGlu (SYM-2081) from GluK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141501(US8921370, 2 | US9656975, 2)
Affinity DataIC50: 3.70nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50116042({7-[3-(4-Benzyl-piperazin-1-ylmethyl)-pyrrol-1-yl]...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141506(US8921370, 160 | US9656975, 160)
Affinity DataIC50: 3.90nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141508(US8921370, 171 | US9656975, 171)
Affinity DataIC50: 4.70nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088223(E-2-Amino-4-(3-naphthalen-1-yl-allyl) -pentanedioi...)
Affinity DataKi:  7nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  8nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141502(US8921370, 6 | US9656975, 6)
Affinity DataIC50: 9nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM85741(NSC_2253 | CAS_140158-50-5 | ATPA)
Affinity DataKi:  9.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088229(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...)
Affinity DataKi:  11.6nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50116048({6-Nitro-2,3-dioxo-7-[3-(4-phenethyl-piperazin-1-y...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  14nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  15nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  15nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50494356(CHEMBL3088070)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088212(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Affinity DataKi:  21nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141503(US8921370, 15 | US9656975, 15)
Affinity DataIC50: 26nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141501(US8921370, 2 | US9656975, 2)
Affinity DataKi:  27nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088228(2-Amino-4-but-2-ynyl-pentanedioic acid | CHEMBL620...)
Affinity DataKi:  28.9nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088216(LY-339296 | E-2-Amino-4-[3-(2-methoxy-phenyl)-ally...)
Affinity DataKi:  30nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088216(LY-339296 | E-2-Amino-4-[3-(2-methoxy-phenyl)-ally...)
Affinity DataKi:  30nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088203(E-2-Amino-4-[3-(4-bromo-phenyl)-allyl]-pentanedioi...)
Affinity DataKi:  30nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088235(E-2-Amino-4-[3-(4-methylsulfanyl-phenyl)-allyl]-pe...)
Affinity DataKi:  32nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141509(US8921370, 176 | US9656975, 176)
Affinity DataIC50: 33nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50091477((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Affinity DataKi:  33nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141504(US8921370, 36 | US9656975, 36)
Affinity DataIC50: 35nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141506(US8921370, 160 | US9656975, 160)
Affinity DataKi:  35nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141510(US8921370, 178 | US9656975, 178)
Affinity DataIC50: 38nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141505(US8921370, 126 | US9656975, 126)
Affinity DataKi:  39nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088224(E-2-Amino-4-[3-(3-methoxy-phenyl)-allyl]-pentanedi...)
Affinity DataKi:  40nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088196(2-Amino-4-(3-chloro-allyl)-pentanedioic acid | CHE...)
Affinity DataKi:  41nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088217(E-2-Amino-4-(3-phenyl-allyl)-pentanedioic acid | C...)
Affinity DataKi:  44nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088221(E-2-Amino-4-[3-(3,4-dichloro-phenyl)-allyl]-pentan...)
Affinity DataKi:  49nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50200526(CHEMBL1234118)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]kainate from human GluK1 expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088200(E-2-Amino-4-[3-(4-trifluoromethyl-phenyl)-allyl]-p...)
Affinity DataKi:  52nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50091474(LY-339637 | (2S,4E)-2-amino-4-(2-methylpropylidene...)
Affinity DataKi:  54nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088213((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...)
Affinity DataKi:  56nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088199(E-2-Amino-4-[3-(4-isopropyl-phenyl)-allyl]-pentane...)
Affinity DataKi:  58nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088234(E-2-Amino-4-[3-(4-nitro-phenyl)-allyl]-pentanedioi...)
Affinity DataKi:  59nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088227(E-2-Amino-4-[3-(3-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  60nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50091481(LY-310683 | (S)-2-Amino-4-propylidene-pentanedioic...)
Affinity DataKi:  61nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141508(US8921370, 171 | US9656975, 171)
Affinity DataKi:  65nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141502(US8921370, 6 | US9656975, 6)
Affinity DataKi:  78nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50088205(E-2-Amino-4-[3-(4-fluoro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  78nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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