Compile Data Set for Download or QSAR
Report error Found 2936 for UniProtKB: O35433
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0230nMAssay Description:In vitro binding affinity towards vanilloid receptor by [3H]RTX displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0426nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50492805(CHEMBL2414497)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50052440(Phenyl-acetic acid (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)...)
Affinity DataKi:  0.0540nMAssay Description:Inhibitory constant for RTX binding to rat spinal cordMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50241485(CHEMBL4060041)
Affinity DataKd:  0.0640nMAssay Description:Binding affinity to rat TRPV1 after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50264967((2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)p...)
Affinity DataIC50: 0.0690nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50247744([(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,...)
Affinity DataKi:  0.0730nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM176555(US9120756, 17)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM369799(US10233177, Example 51)
Affinity DataIC50: 0.100nMAssay Description:Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

LigandPNGBDBM176564(US9120756, 26)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM176564(US9120756, 26)
Affinity DataKi:  0.100nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50275762(CHEMBL4125690)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at recombinant rat TRPV1 expressed in HEK293 cells assessed as reduction in capsaicin-induced Ca2+ flux preincubated for 3 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2020
Entry Details Article
PubMed
LigandPNGBDBM176555(US9120756, 17)
Affinity DataKi:  0.100nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50247741([(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,...)
Affinity DataEC50:  0.106nMAssay Description:Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.120nMAssay Description:Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]RTX binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.120nMAssay Description:Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]RTX binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052442(CHEMBL448382 | resinferatoxin | Resiniferatoxin(RT...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding to Rat Vanilloid receptor 1 (VR1) expressing CHO cells compared to capsaicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50333930([(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dime...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM369798(US10233177, Example 48)
Affinity DataIC50: 0.130nMAssay Description:Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

LigandPNGBDBM50492808(CHEMBL2414501)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50492809(CHEMBL2414498)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50052327(6-hydroxy-15-isopropenyl-4,13,17-trimethyl-5-oxo-(...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]RTX binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50333927([(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dime...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50492805(CHEMBL2414497)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM176554(US9120756, 16)
Affinity DataKi:  0.200nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50247741([(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,...)
Affinity DataKi:  0.228nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50333925([(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dime...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at rat TRPV1 expressed in CHO cells assessed as 45Ca2+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50492806(CHEMBL2414504)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50261646((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50261646((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...)
Affinity DataIC50: 0.300nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50333928([(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dime...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50222640(CHEMBL415543)
Affinity DataIC50: 0.320nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222640(CHEMBL415543)
Affinity DataIC50: 0.320nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50492807(CHEMBL2414502)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50492808(CHEMBL2414501)
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM176549(US9120756, 7)
Affinity DataKi:  0.350nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50264925((S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)py...)
Affinity DataIC50: 0.360nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM86054(5'-IODORESINIFERATOXIN | I-RTX)
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM176562(US9120756, 24)
Affinity DataKi:  0.400nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50191713(N-(4-tert-butylphenyl)-4-[3-(N-methanesulfonylmeth...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM176561(US9120756, 23)
Affinity DataKi:  0.400nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM50241325(N-(4-(2-(1-isobutyl-1,2,3,6-tetrahydropyridin-4-yl...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50247749([(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
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