Compile Data Set for Download or QSAR
Report error Found 33 for UniProtKB: P04233
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50018830BDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50018830BDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664272BDBM50664272(CHEMBL6165880)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185140BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185140BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of ROS1-driven cell viability incubated for 72 hrs by C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCD74-ROS1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of ROS1-driven cell viability incubated for 72 hrs by C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182092BDBM50182092(4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 410nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182108BDBM50182108(1-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 750nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182102BDBM50182102(4-(1-(3-(5-acetyl-3-(4-(trifluoromethyl)phenyl)-4,...)
Affinity DataIC50: 810nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182104BDBM50182104(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 900nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182115BDBM50182115(1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 930nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182110BDBM50182110(4-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)...)
Affinity DataIC50: 950nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182113BDBM50182113(6-chloro-1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(...)
Affinity DataIC50: 980nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182095BDBM50182095(1-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182087BDBM50182087(4-(1-(3-(5-acetyl-3-(4-(trifluoromethyl)phenyl)-4,...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182098BDBM50182098(4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182101BDBM50182101(1-[4-(6-Chloro-2,2-dioxo-3,4-dihydro-2H-2lambda*6*...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182103BDBM50182103(6-chloro-4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182097BDBM50182097(1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182093BDBM50182093(1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182099BDBM50182099(1-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182105BDBM50182105(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182106BDBM50182106(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182109BDBM50182109(1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182118BDBM50182118(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182117BDBM50182117(6-chloro-1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182100BDBM50182100(1-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182094BDBM50182094(5-methyl-4-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluo...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182114BDBM50182114(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182089BDBM50182089(1-[3-(4-Bromo-phenyl)-5-methanesulfonyl-4,5,6,7-te...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHLA class II histocompatibility antigen gamma chain(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182107BDBM50182107(4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of MHC2 invariant chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed