Compile Data Set for Download or QSAR
Report error Found 341 of affinity data for UniProtKB/TrEMBL: P10586
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50262987(Illudalic acid | CHEMBL506661)
Affinity DataIC50: 66nMAssay Description:Covalent inhibition of wildtype LAR catalytic domain D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296375((3S)-6-[4-(2,2-Dimethyl-1,3-dithiolan-4-yl)butylca...)
Affinity DataIC50: 380nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296376((3S)-7-[4-(2,2-Dimethyl-1,3-dithiolan-4-yl)butylca...)
Affinity DataIC50: 382nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326165(oxalylaminobenzoic acid | CHEMBL1241315)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50079855((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Affinity DataIC50: 420nMAssay Description:The compound was tested in vitro for the inhibitory activity against LAR (human Protein-tyrosine phosphatase F)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296374((3S)-7-[2-(2,2-Dimethyl-1,3-dithiolan-4-yl)ethylca...)
Affinity DataIC50: 458nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296373((3S)-6-[2-(2,2-Dimethyl-1,3-dithiolan-4-yl)ethylca...)
Affinity DataIC50: 493nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296372((3S)-7-[3-(2-Thienyl)propylcarboxamido]-isochroman...)
Affinity DataIC50: 625nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50: 690nMAssay Description:Inhibitory activity against LAR protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296371((3S)-6-[3-(2-Thienyl)propylcarboxamido]-isochroman...)
Affinity DataIC50: 765nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM199180(US9217012, 10)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 7.0 T: 2°CAssay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details
US Patent

TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50149232(3-{5-[2-[4-carboxy(2-carboxyphenyl)carboxamido-1-n...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50262987(Illudalic acid | CHEMBL506661)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326151(8-(2-Methylthiazol-4-yl)dibenzo[b,d]furan-4-carbox...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Vanadates | Sodium orthovanadate (S...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50079856([2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thio...)
Affinity DataIC50: 1.50E+3nMAssay Description:The compound was tested in vitro for the inhibitory activity against LAR (human Protein-tyrosine phosphatase F)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50263036(3-Hydroxy-6-methoxy-8,8-dimethyl-1-oxo-1,3,4,7,8,9...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human recombinant LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50250606(CHEMBL4077342)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of LAR (unknown origin) using pNPP as substrate preincubated for 5 mins followed by substrate addition measured for 20 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296382((3S)-7-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326163((E)-8-{2-[4-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326164((E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326156(8-{2-[4-(Piperidin-1-yl)phenyl]thiazol-4-yl}dibenz...)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50262987(Illudalic acid | CHEMBL506661)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50262987(Illudalic acid | CHEMBL506661)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326162(8-[2-(3-Iodophenyl)thiazol-4-yl]dibenzo[b,d]furan-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326158(8-{2-[4-(2,6-Dimethylmorpholino)phenyl]thiazol-4-y...)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296380((3S)-7-[4-(1,2-Dithiolan-3-yl)butylcarboxamido]-is...)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296381((3S)-6-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50099778(4-Phenyl-[1,2]naphthoquinone | CHEMBL51447)
Affinity DataIC50: 2.49E+3nMAssay Description:In vitro inhibitory activity against recombinant human LAR using fluorescein diphosphate (FDP) as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326161(8-[2-(4-Iodophenyl)thiazol-4-yl]dibenzo[b,d]furan-...)
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326153(8-[2-(4-Aminophenyl)thiazol-4-yl]dibenzo[b,d]furan...)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296379((3S)-6-[4-(1,2-Dithiolan-3-yl)butylcarboxamido]-is...)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326152(8-[2-(4-Nitrophenyl)thiazol-4-yl]dibenzo[b,d]furan...)
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326157(8-[2-(4-Morpholinophenyl)thiazol-4-yl]dibenzo[b,d]...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326155(8-{2-[4-(Pyrrolidin-1-yl)phenyl]thiazol-4-yl}diben...)
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against SH-domain containing phosphotyrosine phosphatase-2 (Tyrosine phosphatase SHP2) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326159(8-[2-(4-Carboxyphenyl)thiazol-4-yl]dibenzo[b,d]fur...)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50409191(CHEMBL365490)
Affinity DataIC50: 3.25E+3nMAssay Description:in vitro inhibitory activity against LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50409191(CHEMBL365490)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of LAR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296391((2S)-3-(4-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxa...)
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326160(8-[2-(3,5-Dibromo-4-(1-carboxy-2-phenylethoxy)phen...)
Affinity DataIC50: 3.57E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50326154(8-{2-[4-(Dimethylamino)phenyl]thiazol-4-yl}dibenzo...)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of human recombinant LAR after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50148911(3beta-hydroxyurs-12-en-28-oic acid | (3beta)-3-hyd...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296385((3S)-6-{4-[(4R)-1,3-Dithian-4-yl]butylcarboxamido}...)
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296386((3S)-7-{4-[(4R)-1,3-Dithian-4-yl]butylcarboxamido}...)
Affinity DataIC50: 4.37E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296390((2S)-3-(4-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxa...)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296377((3S)-6-[2-(2,2-Diphenyl-1,3-dithiolan-4-yl)ethylca...)
Affinity DataIC50: 4.98E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296378((3S)-7-[2-(2,2-Diphenyl-1,3-dithiolan-4-yl)ethylca...)
Affinity DataIC50: 5.06E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50290909(CHEMBL4164960)
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of human GST-tagged LAR D1 (1275 to 1613 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50296389((3S)-7-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Affinity DataIC50: 5.86E+3nMAssay Description:Inhibition of LARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
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