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Report error Found 1841 of affinity data for UniProtKB/TrEMBL: P13569
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301431BDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  0.200nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50566263BDBM50566263(CHEMBL4776653)
Affinity DataEC50: <0.310nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50566263BDBM50566263(CHEMBL4776653)
Affinity DataEC50: <0.310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301470BDBM301470(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...)
Affinity DataEC50:  0.400nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595765BDBM50595765(CHEMBL5178232)
Affinity DataEC50:  0.400nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301443BDBM301443(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...)
Affinity DataEC50:  0.410nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301429BDBM301429(US10131670, Example 13 | 4-amino-7-{1-[1-(2-fluoro...)
Affinity DataEC50:  0.420nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301433BDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  0.420nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50516910BDBM50516910(CHEMBL4558190)
Affinity DataEC50:  0.5nMAssay Description:Corrector activity at CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595762BDBM50595762(CHEMBL5193680)
Affinity DataEC50:  0.510nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301431BDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  0.560nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301433BDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  0.560nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301442BDBM301442(4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...)
Affinity DataEC50:  0.570nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301429BDBM301429(US10131670, Example 13 | 4-amino-7-{1-[1-(2-fluoro...)
Affinity DataEC50:  0.620nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301438BDBM301438(4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...)
Affinity DataEC50:  0.660nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595764BDBM50595764(CHEMBL5178488)
Affinity DataEC50:  0.660nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595761BDBM50595761(CHEMBL5202275)
Affinity DataEC50:  0.800nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595763BDBM50595763(CHEMBL5186971)
Affinity DataEC50:  0.840nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301442BDBM301442(4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...)
Affinity DataEC50:  0.860nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50595766BDBM50595766(CHEMBL5171054)
Affinity DataEC50:  0.900nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301443BDBM301443(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...)
Affinity DataEC50:  1.05nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50566262BDBM50566262(CHEMBL4799994)
Affinity DataEC50:  1.10nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663438BDBM50663438(CHEMBL6170767)
Affinity DataEC50:  1.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301463BDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  1.53nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663437BDBM50663437(CHEMBL6170689)
Affinity DataEC50:  1.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301435BDBM301435(4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...)
Affinity DataEC50:  1.67nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663435BDBM50663435(CHEMBL6143326)
Affinity DataEC50:  1.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301449BDBM301449(US10131670, Example 82 | 7-{1-[1-(2-fluorophenyl)-...)
Affinity DataEC50:  1.88nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663463BDBM50663463(CHEMBL6167971)
Affinity DataEC50:  2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663464BDBM50663464(CHEMBL6148174)
Affinity DataEC50:  2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663458BDBM50663458(CHEMBL6175200)
Affinity DataEC50:  2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50035582BDBM50035582(CHEMBL3357142)
Affinity DataEC50:  2nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301431BDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301449BDBM301449(US10131670, Example 82 | 7-{1-[1-(2-fluorophenyl)-...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301451BDBM301451(US10131670, Example 60 | 7-{1-[1-(2,4-difluorophen...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50032694BDBM50032694(CHEMBL3354672)
Affinity DataEC50:  2.10nMAssay Description:Inhibition of CFTR F508 deletion mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301421BDBM301421(4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...)
Affinity DataEC50:  2.13nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663471BDBM50663471(CHEMBL4083374)
Affinity DataEC50:  2.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50566258BDBM50566258(CHEMBL4787310)
Affinity DataEC50:  2.80nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663473BDBM50663473(CHEMBL4077574)
Affinity DataEC50:  3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50035581BDBM50035581(CHEMBL3357141)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50032693BDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50666706BDBM50666706(CHEMBL6177416)
Affinity DataEC50: <3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50035583BDBM50035583(CHEMBL3357143)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301433BDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  3nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50663466BDBM50663466(CHEMBL6171349)
Affinity DataEC50:  3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50032693BDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50666705BDBM50666705(CHEMBL6173991)
Affinity DataEC50: <3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301421BDBM301421(4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...)
Affinity DataEC50:  3.02nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301435BDBM301435(4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...)
Affinity DataEC50:  3.10nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

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