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TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50641938(CHEMBL5573840)
Affinity DataKi:  0.0160nMAssay Description:Binding affinity to recombinant Cathepsin S (unknown origin) expressed in Escherichia coli using Z-Val-Val-Arg-AMC as substrate assessed as inhibitio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM2678(US8524710, 79)
Affinity DataIC50: 0.0290nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50641938(CHEMBL5573840)
Affinity DataKi:  0.0390nMAssay Description:Inhibition of recombinant Cathepsin S (unknown origin) expressed in Escherichia coli using Z-Val-Val-Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101469(US8524710, 47)
Affinity DataIC50: 0.0520nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101470(US8524710, 48)
Affinity DataIC50: 0.0560nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM2718(US8524710, 85 | US8524710, 86 | US8524710, 78)
Affinity DataIC50: 0.0560nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM2724(US8524710, 83)
Affinity DataIC50: 0.0610nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50546794(CHEMBL4777335)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50546794(CHEMBL4777335)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human cathepsin S using Z-VVR-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50243232(N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-P...)
Affinity DataKi: <0.100nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50121575(Morpholine-4-carboxylic acid (1-{[cyano-(2-methyl-...)
Affinity DataKd:  0.100nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50121904([(S)-1-((3S,4R)-2-Oxo-4-phenoxy-azetidin-3-ylcarba...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50401764(CHEMBL2207564)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50401763(CHEMBL2207565)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50121542(Thiophene-2-carboxylic acid {1-[(benzyloxymethyl-c...)
Affinity DataKd:  0.100nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50641925(Petesicatib | Rg7625 | Ro5459072 | RG-7625 | RG762...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM2726(US8524710, 50)
Affinity DataIC50: 0.110nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101473(US8524710, 51)
Affinity DataIC50: 0.130nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19731(2-cyano-4-(cyclohexylamino)-N-(2-phenylethyl)pyrim...)
Affinity DataIC50: 0.130nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50030745(CHEMBL3342185 | acs.jmedchem.1c00409_ST.412)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335289(N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101466(US8524710, 44)
Affinity DataIC50: 0.150nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM2736(US8524710, 80)
Affinity DataIC50: 0.155nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335281(N-(Phenylcarbamoyl)-leucyl-methylazaalanine-nitril...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335283(N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]benzylcar...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101462(US8524710, 40)
Affinity DataIC50: 0.167nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335282(N-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzylcarbamoy...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50030746(CHEMBL3342184 | acs.jmedchem.1c00409_ST.413)
Affinity DataKi:  0.176nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335284(N-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenylcarbamoy...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50546795(CHEMBL4777740)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335278(N-(Benzyloxycarbonyl)-cyclohexylalanyl-methylazala...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50335280(N-(Benzylcarbamoyl)-leucyl-methylazaalanine-nitril...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19511((2R)-3-[(3-bromobenzene)sulfonyl]-N-(1-cyanocyclop...)
Affinity DataIC50: 0.200nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19514((2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzen...)
Affinity DataIC50: 0.200nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19515((2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzen...)
Affinity DataIC50: 0.200nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM101460(US8524710, 38)
Affinity DataIC50: 0.205nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 0.210nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 0.224nMAssay Description:Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19733(2-cyano-4-(cyclohexylamino)-N-[2-(3-methoxyphenyl)...)
Affinity DataIC50: 0.230nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50546796(CHEMBL4761229)
Affinity DataKi:  0.25nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50410979(CHEMBL207347)
Affinity DataKi: <0.25nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50084650({1-[1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-...)
Affinity DataKi:  0.260nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM122478(US8729061, 8)
Affinity DataIC50: 0.296nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19504((2R)-N-(1-cyanocyclopropyl)-3-{[(2,3-difluoropheny...)
Affinity DataIC50: 0.300nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM129694(US8802665, 27)
Affinity DataIC50: 0.300nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM129710(US8802665, 43)
Affinity DataIC50: 0.300nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM19505((2R)-N-(1-cyanocyclopropyl)-3-{[(2,3-difluoropheny...)
Affinity DataIC50: 0.300nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50121558(Morpholine-4-carboxylic acid (1-{[cyano-(2-methyl-...)
Affinity DataKd:  0.300nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50401766(CHEMBL2207562)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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