Compile Data Set for Download or QSAR
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Found 388 of affinity data for UniProtKB/TrEMBL: P28593
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50240622(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093208(2-(5-Bromo-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-bromo-1...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091160(CHEMBL106127 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178811(CHEMBL199020 | N-(3-aminopropyl)-4-tert-butyl-N,N-...)
Affinity DataKi:  150nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096495(CHEMBL85161 | N-{3-[Bis-(3-phenyl-propyl)-amino]-p...)
Affinity DataKi:  151nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  180nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50103373(CHEMBL3398189)
Affinity DataKi:  255nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction of trypanothione disulfide by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093209(2-(5-Methoxy-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-metho...)
Affinity DataKi:  280nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093210(3-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  350nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093205(2-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  390nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM10469(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of Trypanosoma cruzi trypanothione reductase using varying levels of trypanothione disulfide as substrate by Lineweaver--burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  440nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091158(CHEMBL322826 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091165((4-Benzyloxy-benzyl)-[3-(2-chloro-phenothiazin-10-...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091148(CHEMBL106769 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178809(4-tert-butyl-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  570nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096500(CHEMBL86281 | N,N'-Bis-(3-phenyl-propyl)-N,N'-bis-...)
Affinity DataKi:  614nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091162((4-tert-Butyl-benzyl)-[3-(2-chloro-phenothiazin-10...)
Affinity DataKi:  680nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093206(CHEMBL78036 | Spermine derivative)
Affinity DataKi:  750nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091154(CHEMBL106901 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  770nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093211(CHEMBL308396 | Spermine derivative)
Affinity DataKi:  850nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50019879(CHEMBL279905 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091157((2-Adamantan-1-yl-2-oxo-ethyl)-[3-(2-chloro-phenot...)
Affinity DataKi:  1.23E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093204(4-(1H-Indol-3-yl)-N-(3-{4-[3-(4-1H-indol-3-yl-buty...)
Affinity DataKi:  1.26E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091153(Benzyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-di...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096491(CHEMBL85189 | N-(3-Amino-propyl)-N,N'-bis-(3-pheny...)
Affinity DataKi:  1.38E+3nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50093207((E)-3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[(E)-3-(3,...)
Affinity DataKi:  1.39E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091159(CHEMBL326458 | [2-(4-Chloro-3-methyl-phenyl)-2-oxo...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091156((4-Bromo-benzyl)-[3-(2-chloro-phenothiazin-10-yl)-...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091155(CHEMBL323271 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091164(CHEMBL106236 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.67E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178807(3,4-dichloro-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Affinity DataKi:  1.69E+3nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using (ZCG.dmapa)2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091149((4-Chloro-benzyl)-[3-(2-chloro-phenothiazin-10-yl)...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178807(3,4-dichloro-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of Trypanosoma cruzi recombinant trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091150(CHEMBL323540 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50170723(1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide...)
Affinity DataKi:  2.00E+3nMpH: 7.5Assay Description:Inhibitory constant against recombinant Trypanosoma cruzi trypanothione reductase was determined photometrically at 25 degree C in TR assay buffer (4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50240625(4-(2,3,4,9-Tetrahydro-1H-beta-carbolin-1-yl)-benzo...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi recombinant trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50170726(4,4'-Bis(4-benzyloxy-3-methoxybenzimidoylamino)dic...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi recombinant trypanothione reductase by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50170727(4,4'-Bis(4-benzyloxy-3-methoxybenzimidoylamino)-di...)
Affinity DataKi:  2.00E+3nMpH: 7.5Assay Description:Inhibitory constant against recombinant Trypanosoma cruzi trypanothione reductase was determined photometrically at 25 degree C in TR assay buffer (4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50170726(4,4'-Bis(4-benzyloxy-3-methoxybenzimidoylamino)dic...)
Affinity DataKi:  2.00E+3nMpH: 7.5Assay Description:Inhibitory constant against recombinant Trypanosoma cruzi trypanothione reductase was determined photometrically at 25 degree C in TR assay buffer (4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091152(CHEMBL106108 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50278487(CHEMBL3585376)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of 125-I echistatin from Vitronectin receptor (alpha v beta3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50091151((3-Chloro-benzyl)-[3-(2-chloro-phenothiazin-10-yl)...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50178802(4-tert-butyl-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Affinity DataKi:  2.67E+3nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50369578(CHEMBL239370)
Affinity DataKi:  2.98E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of Trypanosoma cruzi recombinant trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096496(CHEMBL62048 | N,N'-Bis-(3-amino-propyl)-N,N'-bis-(...)
Affinity DataKi:  3.48E+3nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096493(CHEMBL82641 | N,N'-Bis-(3-phenyl-propyl)-N-[3-(3-p...)
Affinity DataKi:  3.50E+3nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Southamton

Curated by ChEMBL
LigandPNGBDBM50096496(CHEMBL62048 | N,N'-Bis-(3-amino-propyl)-N,N'-bis-(...)
Affinity DataKi:  3.50E+3nMAssay Description:Compound was evaluated for the competitive inhibition of trypanothione reduction by recombinant Trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails Article
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