Compile Data Set for Download or QSAR
Report error Found 2524 of affinity data for UniProtKB/TrEMBL: P43116
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454064(CHEMBL4217198)
Affinity DataEC50:  0.0680nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454065(CHEMBL4204996)
Affinity DataEC50:  0.0860nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454063(CHEMBL4205480)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156541(CHEMBL3794302)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156474(CHEMBL3793515)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156533(CHEMBL3794016)
Affinity DataEC50:  0.170nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156532(CHEMBL3793862)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156531(CHEMBL3792632)
Affinity DataEC50:  0.210nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM263346(US9546162, 4)
Affinity DataKi:  0.300nM EC50:  11nMpH: 7.4Assay Description:Cells were seeded at a density of 5×104 cells per well in Biocoat Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454062(CHEMBL4212770)
Affinity DataEC50:  0.370nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138101(CHEMBL3754586)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at human EP2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454068(CHEMBL4206444)
Affinity DataEC50:  0.480nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50169613(CHEMBL3806284)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179992(US9676720, Example 2)
Affinity DataKi:  0.530nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156540(CHEMBL3793802)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179995(US9676720, Example 7)
Affinity DataKi:  0.610nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403532(CHEMBL5285583)
Affinity DataKi:  0.630nMAssay Description:Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138052(CHEMBL3751951)
Affinity DataEC50:  0.670nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156538(CHEMBL3794466)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156539(CHEMBL3793892)
Affinity DataEC50:  0.690nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50101830((Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethy...)
Affinity DataKi:  0.740nMAssay Description:Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179994(US9676720, Example 6)
Affinity DataKi:  0.75nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM180045(US9676720, Comparative example 16)
Affinity DataKi:  0.75nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179998(US9676720, Example 11)
Affinity DataKi:  0.790nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179996(US9676720, Example 9)
Affinity DataKi:  0.800nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179993(US9676720, Example 4)
Affinity DataKi:  0.800nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156543(CHEMBL3793045)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50169609(CHEMBL3805981)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50156543(CHEMBL3793045)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM204978(US9249085, I(al) | US9624159, Compound I(al))
Affinity DataEC50:  0.900nMAssay Description:Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM180000(US9676720, Example 14)
Affinity DataKi:  0.900nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138102(CHEMBL3752377)
Affinity DataEC50:  0.910nMAssay Description:Agonist activity at human EP2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179999(US9676720, Example 12)
Affinity DataKi:  0.940nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM180002(US9676720, Example 16)
Affinity DataKi:  0.950nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM179997(US9676720, Example 10)
Affinity DataKi:  0.970nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM180003(US9676720, Example 18)
Affinity DataKi:  0.990nMpH: 6.0Assay Description:Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680058(US12011444, Example 273 | 3-Ethoxy-5-{6-[2-(5,6,7-...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680663(US12011444, Example 878 | 2-Butoxy-4-{6-[2-(6,7-di...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM204981(US9249085, I(ao))
Affinity DataEC50:  1nMAssay Description:Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680024(US12011444, Example 239 | 5-{6-[2-(4-Chloro-6-fluo...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM679997(US12011444, Example 212 | 4-{6-[2-(4-Chloro-2-meth...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM679902(US12011444, Example 117 | 3-Ethoxy-5-{6-[2-(6-meth...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680059(US12011444, Example 274 | 3-Ethoxy-5-{6-[2-(4,6,7-...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680763(US12011444, Example 978 | 7-Fluoro-4-methoxy-1-{2-...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM679835(US12011444, Example 50 | 3-Ethoxy-5-{6-[2-(2-methy...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680060(US12011444, Example 275 | 3-Ethoxy-5-{6-[2-(4,5,7-...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680689(US12011444, Example 904 | 5-{6-[2-(4-Chloro-2-cyan...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM679919(US12011444, Example 134 | 4-{6-[2-(4,7-Difluoro-2-...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680848(US12011444, Example 1063 | 4-{6-[2-(2-Cyano-7-fluo...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM680181(US12011444, Example 396 | 4-{6-[2-(7-Chloro-4-meth...)
Affinity DataIC50: 1nMAssay Description:Stock solutions of test compounds are made at a concentration of 10 mM in DMSO, and serially diluted in DMSO to concentrations required for inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

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