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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM161376(US9108950, 1 | US9724347, Example 1 | US10238658, ...)
Affinity DataKd:  2.00E+4nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
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Date in BDB:
6/12/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
Affinity DataKd:  180nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
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Date in BDB:
6/12/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM161376(US9108950, 1 | US9724347, Example 1 | US10238658, ...)
Affinity DataKd:  2.00E+4nMAssay Description:The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...More data for this Ligand-Target Pair
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Date in BDB:
12/30/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
Affinity DataKd:  180nMAssay Description:The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...More data for this Ligand-Target Pair
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Date in BDB:
12/30/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  28nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
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Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  1.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
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Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  160nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
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Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  2.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
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Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  140nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
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Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM161376(US9108950, 1 | US9724347, Example 1 | US10238658, ...)
Affinity DataKd:  2.00E+4nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
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Date in BDB:
1/18/2016
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM161376(US9108950, 1 | US9724347, Example 1 | US10238658, ...)
Affinity DataKd:  2.00E+4nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
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Date in BDB:
6/13/2021
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
Affinity DataKd:  180nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
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Date in BDB:
6/13/2021
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  213nMAssay Description:Binding affinity to recombinant full-length N-terminal His-GST-tagged GSK3A (unknown origin) expressed in baculovirus infected Sf9 insect cells incub...More data for this Ligand-Target Pair
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Date in BDB:
2/18/2021
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  329nMAssay Description:Binding affinity to recombinant full-length N-terminal His-GST-tagged GSK3A (unknown origin) expressed in baculovirus infected Sf9 insect cells incub...More data for this Ligand-Target Pair
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Date in BDB:
2/18/2021
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  870nMAssay Description:Binding affinity to recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in p...More data for this Ligand-Target Pair
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Date in BDB:
3/23/2022
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd:  580nMAssay Description:Inhibition of wild-type human full length GSK3A (M1 to S483 residues) expressed in bacterial expression system by Kinomescan method relative to contr...More data for this Ligand-Target Pair
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Date in BDB:
8/24/2022
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM187120(US9670161, 1 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)...)
Affinity DataKd:  7.40nMAssay Description:Inhibition of GSK3 alpha (unknown origin) assessed as dissociation constant by DiscoveryX assayMore data for this Ligand-Target Pair
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Date in BDB:
3/5/2023
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50632896(CHEMBL5434183)
Affinity DataKd:  4.30nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
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Date in BDB:
12/22/2024
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
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Date in BDB:
12/22/2024
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50632898(CHEMBL5416758)
Affinity DataKd:  74nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
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Date in BDB:
12/22/2024
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50632905(CHEMBL5414359)
Affinity DataKd:  120nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
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Date in BDB:
12/22/2024
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  240nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
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Date in BDB:
12/22/2024
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  44nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
10/13/2025
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
10/13/2025
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GSK3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  140nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  430nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50237710(AMN 107 | AMN107 | 4-methyl-N-[3-(4-methyl-1H-imid...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM60589(6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd:  280nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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