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TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074661BDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50: 5.20nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074661BDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50: 8.40nMAssay Description:Antagonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha-1/beta-1(Human)
Sanofi R & D

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50446804BDBM50446804(CHEMBL3115061)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at integrin alpha1beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen type-1 after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632657BDBM50632657(CHEMBL5419935)
Affinity DataIC50: 47nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632657BDBM50632657(CHEMBL5419935)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632655BDBM50632655(CHEMBL5410616)
Affinity DataIC50: 83nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632655BDBM50632655(CHEMBL5410616)
Affinity DataEC50:  98nMAssay Description:Agonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632654BDBM50632654(CHEMBL5395825)
Affinity DataIC50: 652nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632654BDBM50632654(CHEMBL5395825)
Affinity DataIC50: 710nMAssay Description:Antagonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632656BDBM50632656(CHEMBL5408335)
Affinity DataIC50: 897nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632658BDBM50632658(CHEMBL5417237)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632656BDBM50632656(CHEMBL5408335)
Affinity DataIC50: 1.11E+3nMAssay Description:Antagonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505772BDBM50505772(CHEMBL4589062)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505782BDBM50505782(CHEMBL4586928)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505772BDBM50505772(CHEMBL4589062)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632659BDBM50632659(CHEMBL5437666)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505782BDBM50505782(CHEMBL4586928)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632660BDBM50632660(CHEMBL5397743)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to alpha1beta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha1/beta2 complex(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632658BDBM50632658(CHEMBL5417237)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandChemical structure of BindingDB Monomer ID 19053BDBM19053((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2007
Entry Details Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandChemical structure of BindingDB Monomer ID 19057BDBM19057((2S)-3-({[(4-aminophenyl)methyl]carbamoyl}amino)-2...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2007
Entry Details Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandChemical structure of BindingDB Monomer ID 19063BDBM19063((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2007
Entry Details Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandChemical structure of BindingDB Monomer ID 19066BDBM19066((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2007
Entry Details Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandChemical structure of BindingDB Monomer ID 19068BDBM19068((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-(naphth...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2007
Entry Details Article
PubMed