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TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582230(CHEMBL5091495)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578383(CHEMBL4870813)
Affinity DataIC50: 1nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582227(CHEMBL5081660)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582229(CHEMBL5080633)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582232(CHEMBL5091603)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582228(CHEMBL5077953)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50582231(CHEMBL5092697)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578381(CHEMBL4860574)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578382(CHEMBL4865978)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578386(CHEMBL4872143)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574356(CHEMBL4845695 | US12252491, Example 27)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578384(CHEMBL4850368)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578385(CHEMBL4851738)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740381(5-cyano-N-((1S)-1- cyclohexyl-2-((2- (methylcarbam...)
Affinity DataIC50: 5.5nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740369(N-(1-(4- ethylcyclohexyl)-2-((2- (methylcarbamoyl)...)
Affinity DataIC50: 5.60nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740335(N-((1S)-1-cyclohexyl- 2-((2- (methylcarbamoyl)-2- ...)
Affinity DataIC50: 5.80nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM548167(WO2022091056, Example 158)
Affinity DataIC50: 6.10nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50573258(CHEMBL4869568)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to biotinylated human IL-17A by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740198(N-(1-(6-chloro-1,2,3,4- tetrahydronaphthalen-2- yl...)
Affinity DataIC50: 6.30nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740228(N-(1-(5-chloro-1,2,3,4- tetrahydronaphthalen-2- yl...)
Affinity DataIC50: 6.5nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740169(N-((1S)-1-((1r,4S)-4- ethylcyclohexyl)-2-((2- (met...)
Affinity DataIC50: 7nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574355(CHEMBL4874078 | US12252491, Example 26)
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740323(N-(1-(4- ethylcyclohexyl)-2-((2- ((R)-4-isopropyl-...)
Affinity DataIC50: 7.5nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM548005(2,4-dimethyl-3-(4-((S)-2-(1-methyl-1H-pyrazole-5-c...)
Affinity DataIC50: 8nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50581144(CHEMBL5087050)
Affinity DataIC50: 9nMAssay Description:Inhibition of IL-17A (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM727042(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574352(CHEMBL4876088 | US12252491, Example 19)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM727041(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574355(CHEMBL4874078 | US12252491, Example 26)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574356(CHEMBL4845695 | US12252491, Example 27)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM727048(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[(1S)-2-methoxy...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM727049(4-Cyclopropyl-N—[(S)-(4,4-difluorocyclohexyl)-[7-[...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM727047(N—[(S)-(4,4-difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574353(CHEMBL4860250 | US12252491, Example 20)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574354(CHEMBL4866932 | US12252491, Example 21)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM727035(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandPNGBDBM726971(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740325(N-((1S)-1-cyclohexyl- 2-((2- (methylcarbamoyl)-2- ...)
Affinity DataIC50: 9.5nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574354(CHEMBL4866932 | US12252491, Example 21)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740131(N-(1-(4- isopropylcyclohexyl)-2- ((2-(methylcarbam...)
Affinity DataIC50: 10nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740397(N-(1-(4- ethylcyclohexyl)-2-((2- (methylcarbamoyl)...)
Affinity DataIC50: 10nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740363(N-((1S)-1-cyclohexyl- 2-((2-(((R)-1- cyclohexyl-2-...)
Affinity DataIC50: 10nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50574352(CHEMBL4876088 | US12252491, Example 19)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM726976(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 10.6nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740184(N-((1S)-1-cyclohexyl-2- ((2-(5-methyl-2-oxo-5- (tr...)
Affinity DataIC50: 10.9nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740215(N-((1S)-1-cycloheptyl- 2-((2-((R)-4-isopropyl- 2-o...)
Affinity DataIC50: 11nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

LigandPNGBDBM727046(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 11.4nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17 receptor A/(Human)
Beigene

US Patent
LigandPNGBDBM740328(N-(2-((2-((R)-4- isopropyl-2- oxoimidazolidin-1-yl...)
Affinity DataIC50: 12nMAssay Description:Compounds disclosed herein were tested for blocking of human IL-17A (Cat: C774, novoprotein) protein with its receptor human IL-17RA (Cat: C153, novo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

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