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TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.100nMAssay Description:Average Binding Constant for CAMK2A; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  0.160nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.160nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.160nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CAMK2a using KKALRRQETVDAL as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of purified mammalian brain calcium calmodulin dependent protein kinase (Ca calmod)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  9nMAssay Description:Binding affinity to recombinant human full-length N-terminal GST-tagged CAMK2A expressed in baculovirus expression system using GS peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  10nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  10nMAssay Description:Binding affinity to CAMK2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  15nMAssay Description:Binding affinity to recombinant human full-length N-terminal GST-tagged CAMK2A expressed in baculovirus expression system using GS peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  20nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  20nMAssay Description:Binding affinity to CAMK2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  20nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM2672(6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430016(CHEMBL2335444)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50217536(CHEMBL2369378)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605602(CHEMBL5175277)
Affinity DataKi:  35nMAssay Description:Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50217537(CHEMBL385035)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430015(CHEMBL2335442)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  46nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430014(CHEMBL2335479)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  80nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  80nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  80nMAssay Description:Binding affinity to CAMK2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  80nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 184nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Thr354Asn mutant expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Ile464His mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Glu355Gln mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Phe467Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Glu355Gln mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Phe467Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Thr412Asn mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Thr412Asn mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Ile414Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605609(CHEMBL5196669)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Ile414Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Ile464His mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50605603(CHEMBL5191835)
Affinity DataKd:  219nMAssay Description:Binding affinity to recombinant human CaMK2alpha Thr354Asn mutant expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 290nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  300nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd:  320nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  350nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  350nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  350nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
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