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TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  1.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  170nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  749nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged AKT3 (unknown origin) (108 to 479 residues) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  537nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged AKT3 (unknown origin) (108 to 479 residues) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50585739(CHEMBL5088272)
Affinity DataKd:  88nMAssay Description:Binding affinity to DNA-tagged AKT3 (unknown origin) assessed as dissociation constant by q-PCR based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50585740(CHEMBL5069422)
Affinity DataKd:  22nMAssay Description:Binding affinity to DNA-tagged AKT3 (unknown origin) assessed as dissociation constant by q-PCR based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50585741(CHEMBL5078791)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to DNA-tagged AKT3 (unknown origin) assessed as dissociation constant by q-PCR based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50585742(CHEMBL5089002)
Affinity DataKd:  23nMAssay Description:Binding affinity to DNA-tagged AKT3 (unknown origin) assessed as dissociation constant by q-PCR based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50586992(CHEMBL5078362)
Affinity DataKd:  8.10nMAssay Description:Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50586993(CHEMBL5091595)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50586994(CHEMBL5073195)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50586995(CHEMBL5082198)
Affinity DataKd:  12nMAssay Description:Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591173(CHEMBL5171347)
Affinity DataEC50:  1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591174(CHEMBL5192394)
Affinity DataEC50:  52nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591175(CHEMBL5178991)
Affinity DataEC50:  402nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591176(CHEMBL5183997)
Affinity DataEC50:  52nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591177(CHEMBL5172011)
Affinity DataEC50:  120nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591178(CHEMBL5203483)
Affinity DataEC50:  564nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591179(CHEMBL5181769)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591180(CHEMBL5200575)
Affinity DataEC50:  102nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591181(CHEMBL5172728)
Affinity DataEC50:  67nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591182(CHEMBL5187719)
Affinity DataEC50:  34nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591183(CHEMBL5170694)
Affinity DataEC50:  33nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50:  13nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591185(CHEMBL5176956)
Affinity DataEC50:  57nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591186(CHEMBL5204086)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50591187(CHEMBL5197756)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  2.84E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  5.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50241256(N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl...)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50241256(N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  6.20E+3nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  4.40E+3nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  170nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  6.20E+3nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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