BDBM139295 US10858323, Compound 1::US8614223, 73

SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1

InChI Key InChIKey=LIIWIMDSZVNYHY-UHFFFAOYSA-N

Data  14 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 139295   

TargetHistone deacetylase 1(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 94nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 128nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 219nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 94nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged full-length human HDAC6 expressed in Sf9 infected baculovirus system using FTS as substrate preincubated for 10 m...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 94nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 128nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 158nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 1.70nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Acetylon Pharmaceuticals Inc

US Patent
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair