BDBM20192 (1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol::cholesterol
SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
InChI Key InChIKey=HVYWMOMLDIMFJA-DPAQBDIFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 20192
Affinity DatapH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
Affinity DataKd: 1.75E+5nMAssay Description:Tryptophan fluorescence measurements were performed with purified FdTSPO1 protein and ligand essentially as described by Li et al.; 2.5 μM prote...More data for this Ligand-Target Pair
Affinity DataKd: 2.02E+5nMAssay Description:Tryptophan fluorescence measurements were performed with purified FdTSPO1 protein and ligand essentially as described by Li et al.; 2.5 μM prote...More data for this Ligand-Target Pair
Affinity DataKd: 68nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Technische Universiteit Eindhoven
Curated by ChEMBL
Technische Universiteit Eindhoven
Curated by ChEMBL
Affinity DataEC50: 418nMAssay Description:Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherich...More data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery
Curated by ChEMBL
Frontier Research Center For Genome & Drug Discovery
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 unitsMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Rattus norvegicus)
Frontier Research Center For Genome & Drug Discovery
Curated by ChEMBL
Frontier Research Center For Genome & Drug Discovery
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 unitsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 8.20E+3nMAssay Description:TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.27E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Technische Universiteit Eindhoven
Curated by ChEMBL
Technische Universiteit Eindhoven
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 p...More data for this Ligand-Target Pair
Affinity DataKd: 60nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair