BDBM26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978

SMILES: CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1

InChI Key: InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N

Data: 7 KI  33 IC50  842 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 884 hits for monomerid = 26474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	22
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase A (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase C (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	750	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 11B (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 11A (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	7.4	25
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.90	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	57	n/a	n/a	n/a	7.4	25
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	98	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	810	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	750	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase ABL1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 6 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL2 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase type 1 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fer (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a
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Cyclin-G-associated kinase (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 10 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase 2, skeletal/cardiac muscle (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase NLK (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 16 (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Interferon-induced, double-stranded RNA-activated protein kinase (Human)	BDBM26474 (GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
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