BDBM26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978

SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1

InChI Key InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N

Data  7 KI  32 IC50  841 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26474   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shandong Institute of Pharmaceutical Industry

LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  43nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Shandong Institute of Pharmaceutical Industry

LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  620nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein-tyrosine kinase(Homo sapiens (Human))
Shandong Institute of Pharmaceutical Industry

LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  5.95E+3nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed