BDBM29589 Faridak::LBH-589::LBH-589B::Panobinostat::US10722597, Compound Panobinostat

SMILES: Cc1c(c2ccccc2[nH]1)CCNCc3ccc(cc3)/C=C/C(=O)NO

InChI Key: InChIKey=FPOHNWQLNRZRFC-UHFFFAOYSA-N

Data: 44 KI  168 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 254 hits for monomerid = 29589   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase (Plasmodium falciparum (isolate 3D7))	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.5	23
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Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 2 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 3 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 4 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	373	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 5 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 7 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.83E+3	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 8 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	231	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 9 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.68E+3	n/a	n/a	n/a	n/a	7.4	25
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Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.61	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 2 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.97	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 3 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.751	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 4 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 5 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	166	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 7 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 8 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51.9	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 9 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Polyamine deacetylase HDAC10 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 11 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bromodomain-containing protein 4 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase (Plasmodium falciparum (isolate 3D7))	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<15	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 3 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 8 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 7 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 2 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 5 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 11 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
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Polyamine deacetylase HDAC10 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 8 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 4 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 9 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	922	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase 6 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 2 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 9 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase 7 (Human)	BDBM29589 (Panobinostat | Faridak | LBH-589B | LBH-589 | US10...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
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